USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: PRS7_HUMAN

USC-OGP 2-DE database:  PRS7_HUMAN


General information about the entry
View entry in simple text format
Entry namePRS7_HUMAN
Primary accession numberP35998
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=26S protease regulatory subunit 7; AltName: Full=26S proteasome AAA-ATPase subunit RPT1; AltName: Full=Proteasome 26S subunit ATPase 2; AltName: Full=Protein MSS1;.
Gene nameName=PSMC2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

Homo sapiens (Human)
  map experimental info

pI=4.69; Mw=25452

Homo sapiens (Human)
  map experimental info

pI=5.83; Mw=47236

UniProtKB/Swiss-ProtP35998; PRS7_HUMAN.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry namePRS7_HUMAN
Primary accession numberP35998
Secondary accession number(s) A4D0Q1 B7Z5E2 Q3LIA5 Q9UDI3
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on March 15, 2017 (version 176)
Name and origin of the protein
DescriptionRecName: Full=26S protease regulatory subunit 7; AltName: Full=26S proteasome AAA-ATPase subunit RPT1; AltName: Full=Proteasome 26S subunit ATPase 2; AltName: Full=Protein MSS1;
Gene nameName=PSMC2
Encoded onName=PSMC2; Synonyms=MSS1
Keywords3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleotide-binding; Nucleus; Proteasome; Reference proteome.
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
EMBLD11094; BAA01868.1; -; mRNA
EMBLAB075520; BAE45763.1; -; mRNA
EMBLAK298821; BAH12878.1; -; mRNA
EMBLCH236947; EAL24412.1; -; Genomic_DNA
EMBLCH471070; EAW83332.1; -; Genomic_DNA
EMBLBC002589; AAH02589.1; -; mRNA
CCDSCCDS5731.1; -. [P35998-1]; .
PIRS24353; S24353; .
RefSeqNP_001191382.1; NM_001204453.1; .
RefSeqNP_002794.1; NM_002803.3. [P35998-1]; .
UniGeneHs.437366; -; .
PDB5GJQ; EM; 4.50 A; H=1-433
PDB5GJR; EM; 3.50 A; H/v=1-433
PDB5L4G; EM; 4.02 A; H=1-433
PDB5T0C; EM; 3.80 A; AA/BA=1-433
PDB5T0G; EM; 4.40 A; A=1-433
PDB5T0H; EM; 6.80 A; A=1-433
PDB5T0I; EM; 8.00 A; A=1-433
PDB5T0J; EM; 8.00 A; A=1-433
PDBsum5GJQ; -; .
PDBsum5GJR; -; .
PDBsum5L4G; -; .
PDBsum5T0C; -; .
PDBsum5T0G; -; .
PDBsum5T0H; -; .
PDBsum5T0I; -; .
PDBsum5T0J; -; .
ProteinModelPortalP35998; -; .
SMRP35998; -; .
BioGrid111674; 158; .
DIPDIP-27554N; -; .
IntActP35998; 56; .
MINTMINT-1163662; -; .
STRING9606.ENSP00000292644; -; .
iPTMnetP35998; -; .
PhosphoSitePlusP35998; -; .
SwissPalmP35998; -; .
BioMutaPSMC2; -; .
DMDM547930; -; .
OGPP35998; -; .
EPDP35998; -; .
MaxQBP35998; -; .
PaxDbP35998; -; .
PeptideAtlasP35998; -; .
PRIDEP35998; -; .
DNASU5701; -; .
EnsemblENST00000292644; ENSP00000292644; ENSG00000161057. [P35998-1]; .
EnsemblENST00000435765; ENSP00000391211; ENSG00000161057. [P35998-1]; .
GeneID5701; -; .
KEGGhsa:5701; -; .
UCSCuc003vbs.4; human. [P35998-1]; .
CTD5701; -; .
DisGeNET5701; -; .
GeneCardsPSMC2; -; .
HPAHPA019238; -; .
HPAHPA049621; -; .
MIM154365; gene; .
neXtProtNX_P35998; -; .
OpenTargetsENSG00000161057; -; .
PharmGKBPA33893; -; .
eggNOGKOG0729; Eukaryota; .
eggNOGCOG1222; LUCA; .
GeneTreeENSGT00550000074978; -; .
HOGENOMHOG000225143; -; .
HOVERGENHBG000109; -; .
InParanoidP35998; -; .
KOK03061; -; .
OrthoDBEOG091G096W; -; .
PhylomeDBP35998; -; .
TreeFamTF105661; -; .
ReactomeR-HSA-1169091; Activation of NF-kappaB in B cells; .
ReactomeR-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; .
ReactomeR-HSA-1236974; ER-Phagosome pathway; .
ReactomeR-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); .
ReactomeR-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; .
ReactomeR-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; .
ReactomeR-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; .
ReactomeR-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; .
ReactomeR-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; .
ReactomeR-HSA-180534; Vpu mediated degradation of CD4; .
ReactomeR-HSA-180585; Vif-mediated degradation of APOBEC3G; .
ReactomeR-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; .
ReactomeR-HSA-195253; Degradation of beta-catenin by the destruction complex; .
ReactomeR-HSA-202424; Downstream TCR signaling; .
ReactomeR-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; .
ReactomeR-HSA-2467813; Separation of Sister Chromatids; .
ReactomeR-HSA-2871837; FCERI mediated NF-kB activation; .
ReactomeR-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; .
ReactomeR-HSA-350562; Regulation of ornithine decarboxylase (ODC); .
ReactomeR-HSA-382556; ABC-family proteins mediated transport; .
ReactomeR-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; .
ReactomeR-HSA-4608870; Asymmetric localization of PCP proteins; .
ReactomeR-HSA-4641257; Degradation of AXIN; .
ReactomeR-HSA-4641258; Degradation of DVL; .
ReactomeR-HSA-5358346; Hedgehog ligand biogenesis; .
ReactomeR-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; .
ReactomeR-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; .
ReactomeR-HSA-5607764; CLEC7A (Dectin-1) signaling; .
ReactomeR-HSA-5610780; Degradation of GLI1 by the proteasome; .
ReactomeR-HSA-5610783; Degradation of GLI2 by the proteasome; .
ReactomeR-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; .
ReactomeR-HSA-5632684; Hedgehog 'on' state; .
ReactomeR-HSA-5658442; Regulation of RAS by GAPs; .
ReactomeR-HSA-5668541; TNFR2 non-canonical NF-kB pathway; .
ReactomeR-HSA-5676590; NIK-->noncanonical NF-kB signaling; .
ReactomeR-HSA-5678895; Defective CFTR causes cystic fibrosis; .
ReactomeR-HSA-5687128; MAPK6/MAPK4 signaling; .
ReactomeR-HSA-5689603; UCH proteinases; .
ReactomeR-HSA-5689880; Ub-specific processing proteases; .
ReactomeR-HSA-6798695; Neutrophil degranulation; .
ReactomeR-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; .
ReactomeR-HSA-68949; Orc1 removal from chromatin; .
ReactomeR-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; .
ReactomeR-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; .
ReactomeR-HSA-69481; G2/M Checkpoints; .
ReactomeR-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; .
ReactomeR-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; .
ReactomeR-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; .
ReactomeR-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; .
ChiTaRSPSMC2; human; .
GeneWikiPSMC2; -; .
GenomeRNAi5701; -; .
PROPR:P35998; -; .
ProteomesUP000005640; Chromosome 7; .
BgeeENSG00000161057; -; .
CleanExHS_PSMC2; -; .
ExpressionAtlasP35998; baseline and differential; .
GenevisibleP35998; HS; .
GOGO:0005737; C:cytoplasm; TAS:UniProtKB; .
GOGO:0005829; C:cytosol; IDA:HPA; .
GOGO:0031597; C:cytosolic proteasome complex; IBA:GO_Central; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0031595; C:nuclear proteasome complex; IBA:GO_Central; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0000932; C:P-body; ISS:UniProtKB; .
GOGO:0022624; C:proteasome accessory complex; ISS:UniProtKB; .
GOGO:0000502; C:proteasome complex; IDA:UniProtKB; .
GOGO:0008540; C:proteasome regulatory particle; base subcomplex; IBA:GO_Central
GOGO:0034774; C:secretory granule lumen; TAS:Reactome; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0016887; F:ATPase activity; IDA:UniProtKB; .
GOGO:0036402; F:proteasome-activating ATPase activity; IBA:GO_Central; .
GOGO:0017025; F:TBP-class protein binding; IBA:GO_Central; .
GOGO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; .
GOGO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome
GOGO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IBA:GO_Central; .
GOGO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; .
GOGO:0000165; P:MAPK cascade; TAS:Reactome; .
GOGO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; .
GOGO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; .
GOGO:0043312; P:neutrophil degranulation; TAS:Reactome; .
GOGO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; .
GOGO:0001649; P:osteoblast differentiation; IDA:UniProtKB; .
GOGO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; .
GOGO:0045899; P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; IBA:GO_Central; .
GOGO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; .
GOGO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; .
GOGO:0016579; P:protein deubiquitination; TAS:Reactome; .
GOGO:0000209; P:protein polyubiquitination; TAS:Reactome; .
GOGO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; .
GOGO:0043488; P:regulation of mRNA stability; TAS:Reactome; .
GOGO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; .
GOGO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; .
GOGO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; .
GOGO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; .
GOGO:0055085; P:transmembrane transport; TAS:Reactome; .
GOGO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; .
GOGO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:UniProtKB; .
GOGO:0016032; P:viral process; IEA:UniProtKB-KW; .
GOGO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome
Gene3D3.40.50.300; -; 1; .
InterProIPR005937; 26S_Psome_P45; .
InterProIPR003593; AAA+_ATPase; .
InterProIPR003959; ATPase_AAA_core; .
InterProIPR003960; ATPase_AAA_CS; .
InterProIPR027417; P-loop_NTPase; .
PfamPF00004; AAA; 1; .
SMARTSM00382; AAA; 1; .
SUPFAMSSF52540; SSF52540; 1; .
TIGRFAMsTIGR01242; 26Sp45; 1; .
PROSITEPS00674; AAA; 1; .

USC-OGP 2-DE database image

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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server